Description
Product Characteristics:
Aliases: 43 kDa ISG15 specific protease antibody, 43 kDa ISG15-specific protease antibody, EC 3.1.2. antibody, hUBP43 antibody, Interferon Stimulated Gene 43 kD antibody, ISG15 Specific Processing Protease antibody, ISG15-specific-processing protease antibody, ISG43 antibody, Ubiquitin Specific Peptidase 18 antibody, Ubiquitin Specific Protease 18 43 kD antibody, Ubiquitin Specific Protease 18 antibody, Ubl carboxyl terminal hydrolase 18 antibody, Ubl carboxyl-terminal hydrolase 18 antibody, Ubl thioesterase 18 antibody, Ubl thiolesterase 18 antibody, Ubp15 antibody, UBP18_HUMAN antibody, USP18 antibody
Target Information: The protein encoded by this gene belongs to the ubiquitin-specific proteases (UBP) family of enzymes that cleave ubiquitin from ubiquitinated protein substrates. It is highly expressed in liver and thymus, and is localized to the nucleus. This protein efficiently cleaves only ISG15 (a ubiquitin-like protein) fusions, and deletion of this gene in mice results in a massive increase of ISG15 conjugates in tissues, indicating that this protein is a major ISG15-specific protease. Mice lacking this gene are also hypersensitive to interferon, suggesting a function of this protein in downregulating interferon responses, independent of its isopeptidase activity towards ISG15. [provided by RefSeq, Sep 2011]